Kihara, A., Akiyama, Y. and Ito, K. (1999) Dislocation of membrane proteins in FtsH-mediated proteolysis. EMBO J. 18, 2970-2981.
Akiyama, Y. (1999) Self-processing of FtsH and its implication for the cleavage specificity of this protease. Biochemistry 38, 11693-11699.
Ito, K., Matsuo, E. and Akiyama, Y. (1999) A class of integral membrane proteins will be overlooked by the "proteome" study that is based on two-dimensional gel electrophoresis. Mol. Microbiol. 31, 1600-1601.
Matsumoto, G., Mori, H. and Ito, K. (1998) Roles of SecG in ATP- and SecA-dependent protein translocation. Proc. Natl. Acad. Sci. USA 95, 13567-13572.
Akiyama, Y., Kihara, A., Mori, H., Ogura, T. and Ito, K. (1998) Roles of the periplasmic domain of Escherichia coli FtsH (HflB) in protein interactions and activity modulation. J. Biol. Chem., 273, 22326-22333.
Mori, H., Sugiyama, H., Yamanaka, M., Sato, K., Tagaya, M. and Mizushima, S. (1998) Amino-terminal region of SecA is involved in the function of SecG for protein translocation into Escherichia coli membrane vesicles. J. Biochem. 124, 122-129.
Kihara, A., Akiyama, Y. and Ito, K. (1998) Different pathways for protein degradation by the FtsH/HflKC membrane-embedded protease complex: an implication from the interference by a mutant form of a new substrate protein, YccA. J. Mol. Biol. 279, 175-1
Akiyama, Y., Erhmann, M., Kihara, A., and Ito, K. (1998) Polypeptide-binding of Escherichia coli FtsH (HflB). Mol. Microbiol. 28, 803-812.
Akiyama, Y., and Ito, K. (1998) FtsH. Handbook of Proteolytic Enzymes (ed. Barrett, A. D., Rawlings, N. D., Woessner, J. F., Jr.). Academic Press, pp1502-1504.
Akiyama, Y., Ogura, T., and Ito, K. (1997) FtsH. in Guidebook to Molecular Chaperones and Protein Folding Factors (ed. M.-J. Gething). Oxford University Press, pp 451-453.
Kihara, A., Akiyama, Y. and Ito, K. (1997) Host regulation of lysogenic decision in bacteriohagel : transmembrane modulation of FtsH (HflB), the cII degrading protease, by HflKC (HflA). Proc. Natl. Acad. Sci USA 94, 5544-5549.
Sone, M., Akiyama, Y. and Ito, K. (1997) Differential in vivo roles played by DsbA and DsbC in the formation of protein disulfide bonds. J. Biol. Chem. 272, 10349-10352.
Akiyama, Y., Kihara, A. and Ito, K. (1996) Subunit a of proton ATPase F 0 sector is a substrate of the FtsH protease in Escherichia coli. FEBS Lett. 399, 26-28.
Kihara, A., Akiyama, Y. and Ito, K. (1996) A protease complex in the Escherichia coli plasma membrane : HflKC (HflA) forms a complex with FtsH (HflB), regulating its proteolytic activity against SecY. EMBO J. 15, 6122-6131.
Akiyama, Y., Kihara, A., Tokuda, H. and Ito, K. (1996) FtsH (HflB) is an ATP-dependent protease selectively acting on SecY and some other membrane proteins. J. Biol. Chem. 271, 31196-31201.
Qu, J.-N., Makino, S.-I., Adachi, H., Koyama, Y., Akiyama, Y., Ito, K., Tomoyasu, T., Ogura, T., and Matsuzawa, H. (1996) The tolZ gene of Escherichia coli is identified as the ftsH gene. J. Bacteriol., 178, 3457-3461.
Shirai Y., Akiyama, Y. and Ito, K. (1996) Suppression of ftsHmutant phenotypes by overproduction of molecular chaperones. J. Bacteriol. 178, 1141-1145.
Kishigami, S., Akiyama, Y. and Ito, K. (1995) Redox states of DsbA in the periplasm of Escherichia coli. FEBS Lett., 364, 55-58.
Homma, T., Yoshihisa, T., Kihara, A., Akiyama, Y. and Ito, K. (1995) Intracellular stability of a fragment of b-galactosidase: effects of amino-terminally fused polypeptides. Biochem. Biophys. Res. Commun., 215, 452-458.
Akiyama, Y. and Ito, K. (1995) A new Escherichia coli gene, fdrA, identified through suppression analysis of dominant negative ftsH mutations. Mol. Gen. Genet. 249, 202-208.
Akiyama, Y., Yoshihisa, T. and Ito, K. (1995) FtsH, a membrane-bound ATPase, forms a complex in the cytoplasmic membrane of Escherichia coli. J. Biol. Chem. 270, 23485-23490.
Kihara, A., Akiyama, Y. and Ito, K. (1995) FtsH is required for proteolytic elimination of uncomplexed forms of SecY, an essential protein translocase subunit. Proc. Natl. Acad. Sci. USA 92, 4532-4536.
Shimoike, T., Taura, T., Kihara, A., Yoshihisa, T., Akiyama, Y., Cannon, K. and Ito, K. (1995) Product of a new gene, syd, functionally interacts with SecY when overproduced in Escherichia coli. J. Biol. Chem. 270, 5519-5526.
Akiyama, Y., Shirai, Y. and Ito, K. (1994) Involvement of FtsH in protein assembly into and through the membrane. II. Dominant mutations affecting FtsH functions. J. Biol. Chem. 269, 5225-5229.
Akiyama, Y., Ogura, T. and Ito, K. (1994) Involvement of FtsH in protein assembly into and through the membrane. I. Mutations that reduce retention efficiency of a cytoplasmic reporter. J. Biol. Chem. 269, 5218-5224.
Taura, T., Akiyama, Y. and Ito, K. (1994) Genetic analysis of SecY: additional export defective mutations and factors affecting their phenotypes. Mol. Gen. Genet. 243, 261-269.
Baba, T., Taura, T., Shimoike, T., Akiyama, Y., Yoshihisa, T. and Ito, K. (1994) A cytoplasmic domain is important for the formation of a SecY-SecE translocator complex. Proc. Natl. Acad. Sci. USA 91, 4539-4543.
Herman, C., Ogura, T., Tomoyasu, T., Hiraga, S., Akiyama, Y., Ito, K., Thomas, R., D’Ari, R. and Bouloc, P. (1993) Cell growth and l phage development controlled by the same essential Escherichia coli gene, ftsH / hflB. Proc. Natl. Acad. Sci. USA 90, 10861-10865.
Akiyama, Y. and Ito, K. (1993) Folding and assembly of bacterial alkaline phosphatase in vitro and in vivo. J. Biol. Chem. 268, 8146-8150.
Taura, T., Baba, T., Akiyama, Y. and Ito, K. (1993) Determinants of the quantitiy of the stable SecY complex in the Escherichia coli cell. J. Bacteriol. 175, 7771-7775.
Mizobata, T., Akiyama, Y., Ito, K., Yumoto, N., and Kawata, Y. (1992) Effects of the chaperonin GroE on the refolding of tryptophanase from Escherichia coli. Refolding is enhanced in the presence of ADP. J. Biol. Chem. 267, 17773-17779.
Akiyama, Y., Kamitani, S., Kusukawa, N., and Ito, K. (1992) In vitro catalysis of oxidative folding of disulfide-bonded proteins by Escherichia colidsbA (ppfA) gene product. J. Biol. Chem. 267, 22440-22445.
Kamitani, S., Akiyama, Y., and Ito, K. (1992) Identification and characterization of an Escherichia coli gene required for the formation of correctly folded alkaline phosphatase, a periplasmic enzyme. EMBO J. 11, 57-62.
Shimoike, T., Akiyama, Y., Baba, T., Taura, T., and Ito, K. (1992) SecY variants that interfere with Escherichia coli protein export in the presence of normal secY. Mol. Microbiol. 6, 1205-1210.
Shimoike, T., Akiyama, Y., Baba, T., Taura, T., and Ito, K. (1992) SecY variants that interfere with Escherichia coli protein export in the presence of normal secY. Mol. Microbiol. 6, 1205-1210.
Ito, K., and Akiyama, Y. (1991) Membrane components of the protein secretion machinery. Meth. Cell Biol. 34, 189-203. (Academic Press)
Ito, K. and Akiyama, Y. (1991) In vivo analysis of integration of membrane proteins in Escherichia coli. Mol. Microbiol. 5, 2243-2253.
Yamane, K., Akiyama, Y., Ito, K., and Mizushima, S. (1990) A positively charged region is a determinant of the orientation of cytoplasmic membrane proteins in Escherichia coli. J. Biol. Chem. 265, 21166-21171.
Nakamura, K., Takamatsu, H., Akiyama, Y., Ito, K., and Yamane, K. (1990) Complementation of the protein transport defect of the Escherichia colisecY mutant (secY24) by B. subtilis secY homologue. FEBS Lett. 273, 75-78.
Baba, T., Jacq, A., Brickman, E., Beckwith, J., Taura, T., Ueguchi, C., Akiyama, Y., and Ito, K. (1990) Characterization of cold-sensitive secY mutants of Escherichia coli. J. Bacteriol. 172, 7005-7010.
Ito, K., Akiyama, Y., Ueguchi, C., Taura, T. and Baba, T. (1990) Structure and function of E. coli SecY protein, an integral membrane component of the protein translocation system. pp. 317-322, Protein Engineering. Protein Design in Basic Research, Medicine and Industry (ed. M. Ikehara), Japan Scientific Societies Press / Springer-Verlag.
Akiyama, Y., Inada, T., Nakamura, Y. and Ito, K. (1990) SecY, a multispanning membrane protein, contains a potential leader peptidase cleavage site. J. Bacteriol. 172, 2888-2893.
Akiyama, Y. and Ito, K. (1990) SecY protein, a membrane embedded secretion factor of E. coli, is cleaved by the OmpT protease in vitro. Biochem. Biophys. Res. Commun. 167, 711-715.
1985〜1989年
Kusukawa, N., Yura, T., Ueguchi, C., Akiyama, Y. and Ito, K. (1989) Effects of mutations in heat-shock genes groES and groEL on protein export in Escherichia coli. EMBO J. 8, 3517-3521.
Ueguchi, C., Wittekind, M., Nomura, M., Akiyama, Y. and Ito, K. (1989) The secY-rpmJ region of the spc ribosomal protein operon in Escherichia coli : structural alterations affecting secY expression. Mol. Gen. Genet. 217, 1-5.
Ito, K., Hirota, Y. and Akiyama, Y. (1989) Temperature-sensitive sec mutants of Escherichia coli: inhibition of protein export at the permissive temperature. J. Bacteriol. 171,1742-1743.
Akiyama, Y. and Ito, K. (1989) Export of Escherichia coli alkaline phosphatase attached to an integral membrane protein, SecY. J. Biol. Chem. 264, 437-442.
Akiyama, Y. and Ito, K. (1987) : Topology analysis of the SecY protein, an integral membrane protein involved in protein export in Escherichia coli. EMBO J. 6, 3465-3470.
Akiyama, Y. and Ito, K. (1986) : Overproduction, isolation, and determination of the amino-terminal sequence of the SecY protein, a membrane protein involved in protein export in Escherichia coli. Eur. J. Biochem. 159, 263-266.
Akiyama, Y. and Ito, K. (1985) : The SecY membrane component of the bacterial protein export machinery : Analysis by new electrophoretic methods for integral membrane proteins. EMBO J. 4, 3351-3356.
